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Publikationen

  1. Universitätsklinik für Innere Medizin II
  2. Unsere Abteilungen
  3. Pulmologie
  4. Klinische Schwerpunkte
  5. Forschungslabor
  6. Publikationen

Ausgewählte Publikationen des Labors

  1. Kargarpour, Z., Cicko, S., Kohler, T.C., Zech, A., Stoshikj, S., Bal, C., Renner, A., Idzko, M., and El-Gazzar, A. (2023). Blocking P2Y2 purinergic receptor prevents the development of lipopolysaccharide-induced acute respiratory distress syndrome. Front Immunol 14, 1310098. 10.3389/fimmu.2023.1310098.
  2. Schneble, D., El-Gazzar, A., Kargarpour, Z., Kramer, M., Metekol, S., Stoshikj, S., and Idzko, M. (2023). Cell-type-specific role of P2Y2 receptor in HDM-driven model of allergic airway inflammation. Front Immunol 14, 1209097. 10.3389/fimmu.2023.1209097.
  3. El-Gazzar, A., Voraberger, B., Rauch, F., Mairhofer, M., Schmidt, K., Guillemyn, B., Mitulovic, G., Reiterer, V., Haun, M., Mayr, M.M., et al. (2023). Bi-allelic mutation in SEC16B alters collagen trafficking and increases ER stress. EMBO Mol Med 15, e16834. 10.15252/emmm.202216834.
  4. Jain, S., Pydi, S.P., Toti, K.S., Robaye, B., Idzko, M., Gavrilova, O., Wess, J., and Jacobson, K.A. (2020). Lack of adipocyte purinergic P2Y(6) receptor greatly improves whole body glucose homeostasis. Proc Natl Acad Sci U S A 117, 30763-30774. 10.1073/pnas.2006578117.
  5. Schmidt, S., Bonilla, W.V., Reiter, A., Stemeseder, F., Kleissner, T., Oeler, D., Berka, U., El-Gazzar, A., Kiefmann, B., Schulha, S.C., et al. (2020). Live-attenuated lymphocytic choriomeningitis virus-based vaccines for active immunotherapy of HPV16-positive cancer. Oncoimmunology 9, 1809960. 10.1080/2162402X.2020.1809960.
  6. Nagai, J., Balestrieri, B., Fanning, L.B., Kyin, T., Cirka, H., Lin, J., Idzko, M., Zech, A., Kim, E.Y., Brennan, P.J., and Boyce, J.A. (2019). P2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation. J Clin Invest 129, 5169-5186. 10.1172/JCI129761.
  7. Faliti, C.E., Gualtierotti, R., Rottoli, E., Gerosa, M., Perruzza, L., Romagnani, A., Pellegrini, G., De Ponte Conti, B., Rossi, R.L., Idzko, M., et al. (2019). P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus. J Exp Med 216, 317-336. 10.1084/jem.20171976.
  8. Steculorum, S.M., Paeger, L., Bremser, S., Evers, N., Hinze, Y., Idzko, M., Kloppenburg, P., and Bruning, J.C. (2015). Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons. Cell 162, 1404-1417. 10.1016/j.cell.2015.08.032.
  9. Idzko, M., Ferrari, D., and Eltzschig, H.K. (2014). Nucleotide signalling during inflammation. Nature 509, 310-317. 10.1038/nature13085.
  10. El-Gazzar, A., Cai, X., Reeves, R.S., Dai, Z., Caballero-Benitez, A., McDonald, D.L., Vazquez, J., Gooley, T.A., Sale, G.E., Spies, T., and Groh, V. (2014). Effects on tumor development and metastatic dissemination by the NKG2D lymphocyte receptor expressed on cancer cells. Oncogene 33, 4932-4940. 10.1038/onc.2013.435.
  11. Jankovic, D., Ganesan, J., Bscheider, M., Stickel, N., Weber, F.C., Guarda, G., Follo, M., Pfeifer, D., Tardivel, A., Ludigs, K., et al. (2013). The Nlrp3 inflammasome regulates acute graft-versus-host disease. J Exp Med 210, 1899-1910. 10.1084/jem.20130084.
  12. El-Gazzar, A., Groh, V., and Spies, T. (2013). Immunobiology and conflicting roles of the human NKG2D lymphocyte receptor and its ligands in cancer. J Immunol 191, 1509-1515. 10.4049/jimmunol.1301071.
  13. Weber, F.C., Esser, P.R., Muller, T., Ganesan, J., Pellegatti, P., Simon, M.M., Zeiser, R., Idzko, M., Jakob, T., and Martin, S.F. (2010). Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity. J Exp Med 207, 2609-2619. 10.1084/jem.20092489.
  14. Wilhelm, K., Ganesan, J., Muller, T., Durr, C., Grimm, M., Beilhack, A., Krempl, C.D., Sorichter, S., Gerlach, U.V., Juttner, E., et al. (2010). Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R. Nat Med 16, 1434-1438. 10.1038/nm.2242.
  15. Idzko, M., Hammad, H., van Nimwegen, M., Kool, M., Willart, M.A., Muskens, F., Hoogsteden, H.C., Luttmann, W., Ferrari, D., Di Virgilio, F., et al. (2007). Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat Med 13, 913-919. 10.1038/nm1617.