Keywords

Acute Coronary Syndrome; Inflammation Mediators; Neutrophil Activation

Research group(s)

• Research group Irene Lang
  Members:
  Thomas M Hofbauer
  Adelheid Panzenböck
  Anna S. Ondracek

Research interests

My main research topic focuses on innate immune mechanisms in cardiovascular disease. Particularly, we investigate neutrophil effector function to understand formation of neutrophil extracellular traps (NETs) in acute coronary syndrome and stable coronary artery disease. We aim for a translational approach to elucidate the role of high lipid levels on the balance between NET formation and degradation.

Techniques, methods & infrastructure

At the Anna Spiegel Research Center we have the infrastructure to conduct research in translational biomedicine applying the most advanced techniques in molecular biology, flow cytometry, cell and tissue culture, immunohistochemistry, and immunofluorescence.

Selected publications

1. Ondracek, A.S. et al. (2020) ‘Imbalance between plasma double-stranded DNA and deoxyribonuclease activity predicts mortality after out-of-hospital cardiac arrest’, Resuscitation, 151, pp. 26–32. Available at: http://dx.doi.org/10.1016/j.resuscitation.2020.03.006.
2. Hofbauer, T.M. et al. (2020) ‘Neutrophil Extracellular Traps Induce MCP-1 at the Culprit Site in ST-Segment Elevation Myocardial Infarction’, Frontiers in Cell and Developmental Biology, 8. Available at: http://dx.doi.org/10.3389/fcell.2020.564169.
3. Räber, L. et al. (2022) ‘Effect of Alirocumab Added to High-Intensity Statin Therapy on Coronary Atherosclerosis in Patients With Acute Myocardial Infarction’, JAMA, 327(18), p. 1771. Available at: http://dx.doi.org/10.1001/jama.2022.5218.
4. Ondracek, A.S. et al. (2022) ‘Physical Exercise Promotes DNase Activity Enhancing the Capacity to Degrade Neutrophil Extracellular Traps’, Biomedicines, 10(11), p. 2849. Available at: http://dx.doi.org/10.3390/biomedicines10112849.
5. Mangold, A. et al. (2021) ‘Culprit site extracellular DNA and microvascular obstruction in ST-elevation myocardial infarction’, Cardiovascular Research, 118(8), pp. 2006–2017. Available at: http://dx.doi.org/10.1093/cvr/cvab217.