Aortic Valve Stenosis; Genomics; Hypertension; Hypertension, Pulmonary; Myocardial Infarction
My main research focus is to understand the processes underlying the development and progression of degenerative aortic valve disease. There exists no medical treatment for this disease, and once patients develop severe symptoms aortic valve replacement is the only treatment option. We aim to elucidate the role of endothelial cell dysfunction utilizing human tissue samples as well as animal models. This might help to improve the understanding of this disease, and may lead to the identification of new therapeutical targets. Beside degenerative aortic valve disease I am also involved in studies targeting pulmonary hypertension, single nucleotide polymorphisms (SNPs) influencing blood pressure and thrombosis and myocardial infarction.
Techniques, methods & infrastructure
Isolation, processing and qualitiy-control of RNA, DNA and protein from blood and tissue samples, Real-time PCR and SNP Genotyping, Analysis of Imunohistochemical and Histochemical Tissue Stains utilizing an automated Scan-Microscope and Analysis Software (TissueFAXS), Life-cell imaging, Ultrasound in Mouse