Aortic Valve Stenosis; Genomics; Hypertension; Hypertension, Pulmonary; Myocardial Infarction
My main research focus is to understand the processes underlying the development and progression of degenerative aortic valve disease. There exists no medical treatment for this disease, and once patients develop severe symptoms aortic valve replacement is the only treatment option. We aim to elucidate the role of endothelial cell dysfunction utilizing human tissue samples as well as animal models. This might help to improve the understanding of this disease, and may lead to the identification of new therapeutical targets. Another important field we are working on is Pulmonary Hypertension. One of our Projects focuses on the roleof monocytes and their effector mechanisms in PH. Especially the balance between proinflammatory capacities like the production of cytokines, and anti-inflammatory functions such as efferocytosis, the removal of apoptotic cells, is of key interest here. We currently perform a study supported by the ÖNB utilizing masscytometry (CyTOF) to perform deep profiling of clinical samples on a single-cell level. I am also involved in studies targeting single nucleotide polymorphisms (SNPs) influencing blood pressure, thrombosis and myocardial infarction.
Techniques, methods & infrastructure
Isolation, processing and qualitiy-control of RNA, DNA and protein from blood and tissue samples, Real-time PCR and SNP Genotyping, Analysis of Imunohistochemical and Histochemical Tissue Stains utilizing an automated Scan-Microscope and Analysis Software (TissueFAXS), Life-cell imaging, Ultrasound in Mouse