Keywords

Acute Coronary Syndrome; Neutrophil Activation; Pulmonary Artery

Research group(s)

• Research group Irene Lang
  Members:
  Thomas M Hofbauer
  Adelheid Panzenböck
  Anna S. Ondracek

Research interests

My main focus is to understand the importance of the innate immune system in cardiovascular disease. Specifically, our group emphasizes the role of Neutrophil Extracellular Traps (NETs), an effector mechanism of neutrophil granulocytes, in the pathogenesis of acute myocardial infarction, stable coronary artery disease and arterial hypertension.

Techniques, methods & infrastructure

Bench

Flow cytometry, enzyme-linked immunosorbent assay, cell culture-based functional assays, immunohistochemistry and immunofluorescence, quantitative polymerase chain reaction.

Translational aspects

Connection of experimental and laboratory measurements with clinical features and mortality of affected patients.

Selected publications

1. Hofbauer, T.M. et al., 2019. Neutrophil extracellular traps and fibrocytes in ST-segment elevation myocardial infarction. Basic Research in Cardiology, 114(5). Available at: http://dx.doi.org/10.1007/s00395-019-0740-3.
2. Schmid, D. & Hofbauer, T.M., 2019. The Porcine Coronary Artery Ring Myograph System. Learning Materials in Biosciences, pp.355–374. Available at: http://dx.doi.org/10.1007/978-3-030-12270-6_16.
3. Mangold, A. et al., 2015. Coronary Neutrophil Extracellular Trap Burden and Deoxyribonuclease Activity in ST-Elevation Acute Coronary Syndrome Are Predictors of ST-Segment Resolution and Infarct Size. Circulation Research, 116(7), pp.1182–1192. Available at: http://dx.doi.org/10.1161/CIRCRESAHA.116.304944.
4. Mangold, A. et al., 2019. Neutrophil extracellular traps and monocyte subsets at the culprit lesion site of myocardial infarction patients. Scientific Reports, 9(1). Available at: http://dx.doi.org/10.1038/s41598-019-52671-y.