Animal Experimentation; Cardiac Imaging Techniques; Regenerative Medicine
My main research focus is the cardiac regenerative medicine, and associated basic research, using "omics" (transcriptomics, etc) technology, cell culture and imaging. My research includes experimental cardiac regeneration therapy with cell-based or cell-free or tissue engineered products. My team works on translational projects using experimental models of human cardiovascular diseases, such as different myocardial infarction models, conditioning of the heart, ventricular remodeling, and ischemic cardiomyopathies. Further applied research includes implantation of medical devices under experimental conditions, such as stents, closure devices (ASD, PFO, LAA), artificial heart valves, pacemakers, to evaluate the underlying histology and tissue reactions. I have a broad international scientific cooperation, performing several animal studies in the field of regenerative medicine.
Techniques, methods & infrastructure
Our lab has the facilities for molecular biology works, cell cultures, automated PCR, we use methods for preparation of samples for gene expressions and associated analyses. We have molecular imaging technology, fluorescent microscop and video microscopy to look at the cultivated cells subjected to different substances, eg. cells. secretome, miRNA. The other type of lab work includes the histology of explanted medical devices, such as stents, closure devices, valves, with paraffin or plastic embedding, staining and analyses, to understand the underlying pathology and tissue reaction.
Our team perform large animal experiments with high translational value, simulating diverse human cardiovascular diseases, and involved in several European Commission projects, and other industry-sponsored trials.