Acute Coronary Syndrome; Anticoagulants; Blood Platelets; Cardiology; Coronary Artery Disease; Embolism and Thrombosis
My main research interest is the field of cardiovascular thrombosis. As a PhD student I carried out research on thrombin effects in vivo and in vitro. Thereafter, I expanded my research to fields of arterial thrombosis and personalized antiplatelet therapy. My publications have added to a debate in the cardiology community surrounding the efficacy and safety of conventional antiplatelet treatment. I have background in response variability to platelet inhibitors. In particular, I described the link between high platelet reactivity to clopidogrel and ischemic risk, the correlation between clinical factors and platelet reactivity, and the effect of genetic polymorphisms and drug-drug interactions on the pharmacodynamics of antiplatelet drugs and clinical outcomes in patients with cardiovascular disease. Subsequently, I focused my research on characterization of von Willebrand Factor aptamers ARC15105 and ARC1779. During these years, I acquired skills in biomedical statistics and modeling, including methods of meta-analyses, modeling of scores and algorithms as well as path analyses.
Techniques, methods & infrastructure
Clinical studies, platelet reactivity testing, genetic testing, statistical modeling, meta-analysis, path analysis.